Polypeptide Hormones CJC-1295 with DAC Anti Aging Hormones Acetate
Growth Hormone CJC-1295
1. Quick Detail:
Unit Size :2 mg/vial
Unit Quantity :1 Vial
CAS NO. :863288-34-0
Synonyms :CJC1295/DAC, CJC-1295 with dac, CJC 1295
Molecular Formula :C165H269N47O46
Molecular Weight :3647.19
Appearance :White Powder
Identity (ESI-MS) :3647.19±3.0
Source :Chemical Synthesis
Storage :Lyophilized CJC-1295 W/ DAC is stable at room temperature
for 90 days,however it should be stored in a freezer
below -8C for any extended period of time. After reconstituting CJC-1295
W/ DAC should be
refrigerated at temperatures not to exceed 36 F.
CJC-1295 is a derivative of human GH-releasing
factor1-29(HGRF1-29). HGRF1-29 is a naturally
occurring peptide that is actually a truncated form of a larger
peptide that binds to the growth hormone
secretagogue receptor (GHS-R) and causes the release of growth
hormone. CJC-1295 has
four amino acids substituted in its chain that result in strong
binding to serum albumin and
prolong its half-life in the body.
Because of the way CJC-1295 is engineered its half life has been
extended from ~7 minutes to
greater than 7 days!. This is convenient as it means the product only needs to be injected
1-2 times per week for continuously elevated levels of Human Growth
Hormone (HGH) and
IGF-1. A single subcutaneous (sc) injection results in measurable
quantities of CJC-1295
in the blood for up to 13 days. Additionally, a single dose of 60
ug/kg of CJC-1295 results in
elevated levels of growth hormone (125%) while the pulsatile
secretion of GH is
maintained. Furthermore, 60 ug/kg of CJC-1295 elevated IGF-1 levels
to the upper limit of normal.
A dose of 30 ug/kg of CJC-1295 given weekly maintained its response
with no evidence of
The advantage of using CJC-1295 instead of actual HGH injections is
that injecting HGH
shuts down the body's own natural
production and therefore when injections are ceased, the body’s
ability to produce it's own HGH may
be impaired and take some time to recover. Since CJC-1295 only
stimulates the body's own HGH
production, this risk is not apparent.
Another very positive benefit of CJC-1295/CJC-1293 is its ability
to promote slow wave sleep.
Slow wave sleep is also known as deep sleep and is the
portion of sleep responsible for the highest level of muscle growth
and memory retention. SWS are
decreased significantly in older adults and also with people who
tend to exercise later in the evening.
This peptide has a benefit to side effect ratio that exceeds all
others currently being legally sold and
would make a great addition to ones training regimen or post cycle
Clinical Research was first conducted for CJC-1295 during the
mid-2000s. The objective of the peptide
was to treat visceral fat deposits in obese AIDS patients, as
increased levels of exogenous hgH are
presumed to increase lipolysis (fat loss). The clinical research
was ultimately successful for most
Those looking for anti-aging benefits, improved physique and sense
of well being.
Administration of single doses of CJC-1295 resulted in a 2- to
10-fold increase in mean
serum GH levels in all dosing groups, which was dose incremental
and persisted for up to 6 days.
Similarly, a dose-related increase in mean serum IGF-I levels was
observed at all dose levels,
ranging from 1.5- to 3-fold and persisting for up to 14 days.
Administration of ascending
multiple doses of CJC-1295 resulted in elevated levels of GH,
similar to those observed after
a single dose.
In contrast, elevations in IGF-I levels showed a progressive effect
over time, particularly in
subjects receiving CJC-1295 every 7 d. Results of the multiple-dose
study suggest both a
cumulative pharmacokinetic effect [i.e. persistence of elevated predose levels
of IGF-I in all dosing
groups except group 1 (i.e. two injections of 30 µg/kg)] and a
pituitary priming effect (i.e.progressively
greater Cmax and progressively shorter Tmax after serial dosing).
The data indicate that a minimum
dosing interval of 7 d appears reasonable. The most appropriate
dosing interval will be determined
based on actual efficacy and safety data from longerterm therapeutic studies in patients with various
clinical conditions.No serious adverse reactions were reported in either study. The
reported adverse events in subjects receivingCJC 1295 were injection site reactions, consisting of
transient pain, swelling, and induration that were sometimes accompanied by local
Injection site reactions tended to be more severe and/or prolonged
at higher dose levels. Headache,
diarrhea, and flushing were also observed, with occasional
transient and mild hypotension, but
occurred primarily at higher doses.Adverse effects complicate the use of GH in the treatment of
HIV-associated metabolic conditions such as wasting and
lipodystrophy. Although increases in the
daily dose of GH from 1 to 6 mg are associated with dose-responsive
benefits, doses of 2–3 mg/d
or greater are associated with edema, arthralgias, and glucose
intolerance. These side effects can
become dose limiting. In the current studies, none of the subjects
experienced these adverse effects.
Future clinical trials on this disorder will confirm whether the
use of GHRH rather than GH will
circumvent these problems, as has been suggested in recent
In summary, a single sc administration of CJC-1295 produced
sustained elevations of serum GH
and IGF-I levels in normal subjects for nearly 2 wk. Weekly or biweekly administration of CJC-1295
resulted in stimulation of GH and IGF-I secretion for at least 7 d. Both single and multiple doses of
CJC-1295 over 2 wk were safe and generally well tolerated, particularly at doses of 30 and 60 µg/kg.
Future studies are indicated to evaluate the clinical utility of treatment
with CJC-1295 in patients with
intact GH secretory capacity.
Now for any GH releaser’s benefits to reach full potential,
somatostatin has to be controlled because
it will inhibit gh release. Using an agent known as an
Acetylcholinesterase inhibitor will allow acetyl
chlorine levels to rise by preventing acethylcholineesterase from
overriding acetylcholine; acetylcholine
will inhibit somastostatin production. An example of a natural
acetylcholinieestarase would be
Huzperine A. A recommended dosage for HuzperineA would be around
50mcg. Now as mentioned
before a more potent pharm grade somastostatin inhibitor would be
Logically speaking it would make PERFECT sense to combine CJC-1295
with Ipamorelin since
you get the increase in GH from CJC and the increase of GH pulse
frequencies with a reduction in
somatostatin from the Ipamorelin. This leads to a maximal GH
release effect, thus allowing for
maximum anabolism from optimized GH without desensitization.
Polypeptide Hormones we supply
timulate the body’s tanning response
help enhance mental sharpness,enhance memory
Delta sleep-inducing peptide, abbreviated DSIP
Mainly used for prostate cancer
used in the treatment of HIV-associated lipodystrophy
used as the acetate or pamoate salts
the fat-reducing effects
Pentadecapeptide BPC 157
increasing lean muscular tissue mass, reducing fat
oincrease muscle growth
used for stimulation of uterus contractions
Increases the development of lean body mass
the treatment of growth hormone secretion deficiency
a selective growth hormone secretagogue
endogenous melanocortine peptide
used by bodybuilders and athletes
cause site specific muscle growth
CJC-1295 Without DAC
increasing binding affinity to the GHRH receptors
CJC-1295 with DAC
improved physique and sense of well being
increase libido effects of both men and women
growth hormone stimulation
Increase in strength,Muscle mass,Body fat loss
increases in endurance,strength and muscle growth
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