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Osthol Cnidium Monnieri Extract Hot Sex Women and Animal Plant Osthole CAS 484-12-8 Food Additive With High Quality

Categories Pharmaceutical Raw Materials
Brand Name: TINGYI
Model Number: 484-12-8
Certification: GMP, SGS , ISO 9001:2008 , KOSHER
Place of Origin: China
MOQ: Negotiation
Price: Contact Us
Payment Terms: Western Union, MoneyGram, Bank Transfer, Bitcoin
Supply Ability: 100 KG/Month
Delivery Time: Within 7 Work Days
Packaging Details: Stealth And Discreet Packaging
Product Name: Osthole
Other Name: OSTHOL
CAS: 484-12-8
Appearance: Brown Powder
Catagoty: Food Additives
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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    Osthol Cnidium Monnieri Extract Hot Sex Women and Animal Plant Osthole CAS 484-12-8 Food Additive With High Quality


    Osthol Cnidium Monnieri Extract Hot Sex Women and Animal Plant Osthole CAS 484-12-8 Food Additive With High Quality


    Osthole


    CAS:484-12-8

    MF:C15H16O3

    MW:244.29

    Synonyms:OSTHOL;OSTHOLE;AKOS 236-34;7-Methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;7-METHOXY-8-(3-METHYL-BUT-2-ENYL)-CHROMEN-2-ONE;8-(3-METHYL-2-BUTENYL)HERNIARIN;Chuanxiongzine;Cnidium lactone(OSTHOLE )

    Properties

    Melting point:83-84°C

    storage temp. room temp

    solubility methanol: soluble10mg/mL, clear, colorless


    Abstract


    Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects.1 Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK. It also demonstrates antifibrotic effects in both hepatic and myocardial tissues and has been suggested to be a natural activator of defective delta F508-cystic fibrosis transmembrane conductance regulator chloride channel gating.

    Cnidium monnieri is one of the most widely used traditional herbal medicines and its fruits have been used to treat a variety of diseases in China, Vietnam, and Japan. 350 compounds have been isolated and identified from C. monnieri, including the main active constituent, coumarins. In vitro and in vivo studies suggest that osthole and other coumarin compounds possess wide range of pharmacological properties for the treatment of female genitals, male impotence, frigidity, skin-related diseases, and exhibit strong antipruritic, anti-allergic, antidermatophytic, antibacterial, antifungal, anti-osteoporotic effects.


    Application


    1.Osthole is widely used in fields of heath products. Osthole can be used as the tonic product on

    the male impotence, active ingredients of medicines for gynecological diseases.


    2.Osthole is widely used in fields of medicine products. Osthole also is used as the tonic product

    on the acute exudative skin disease.


    Function


    1.With the tonic effect on the male impotence, there is great effect for treating impotence,it can increase sperm secretion, stimulate sexual desire and has aphrodisiac action.


    2.It can warm the kidney and relieve asthma.


    3.With the role of anti-trichomonas, there is great effect for common gynecological diseases of women.


    4.It can dry dampness and kills worms as well as expel cold and the wind.


    5.With the good effect for treating acute exudative skin diseases.



    Specification


    Identification

    Cnidium Monnieri Extract

    Used Part

    Seed

    Appearance

    Brown powder

    Active Ingredient

    Osthole


    Osthole

    CAS NO.

    484-12-8

    Molecular Formula

    C15H16O3

    Molecular Weight

    244.29

    Loss on Drying

    <=5.0%

    Ash content

    <=5.0%

    Residual Solvent

    Ethanol <=5000ppm

    Total Heavy Metals

    ≤10ppm

    Total Plate Count

    ≤5000cfu/g

    Total Yeast & Mold

    ≤100cfu/g


    Benefits

    Osthole benefit for fatty liver:
    Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.


    Planta Med. 2007.
    The objectives of this study were to determine the therapeutic effect of osthole, an active constituent isolated from Cnidium monnieri, in hyperlipidemic fatty liver rats and investigate the possible mechanism of the osthole treatment. Osthole exerts therapeutic effects on fat milk-induced fatty liver in rats, by regulating mRNA expression of the target genes of CYP7A, DGAT, L-FABP and FATP4 via increasing the PPARalpha/gamma mRNA expression.

    Liver cancer:
    Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas.


    Curr Med Chem Anti-Cancer Agents. 2005.


    The normalization of plasma alanine aminotransferase (ALT) has been proved to be a strategy for preventing the development of hepatocellular carcinoma in hepatitis C virus (HCV)-infection. Glycyrrhizin, a plant medicine, normalizes plasma ALT and prevents HCC. However, glycyrrhizin is administered intravenously and thereby chemical which is effective on oral administration is required. Coumarin compounds are active components of herbs used for the treatment of various diseases. The ability of coumarin compounds to lower plasma ALT were examined using mice concanavalin A-induced hepatitis and mice anti-Fas antibody-induced hepatitis. We conclude that osthole will become a leading chemical for synthesizing a compound which prevents liver cancer on oral administration.

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