storage temp. room temp
solubility methanol: soluble10mg/mL, clear, colorless
Osthole is a natural coumarin that was first isolated from several
medicinal plants, including C. monnieri and A. pubescens. It is
reported to induce a nonspecific elevation of cAMP and cGMP levels
through its ability to inhibit phosphodiesterases, which leads to a
modulation of calcium channel signaling and vasorelaxant effects.1
Osthole exhibits immunomodulatory, antioxidative, and
anti-inflammatory properties, by regulating the expression of
TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide,
ERK, and JNK. It also demonstrates antifibrotic effects in both
hepatic and myocardial tissues and has been suggested to be a
natural activator of defective delta F508-cystic fibrosis
transmembrane conductance regulator chloride channel gating.
Cnidium monnieri is one of the most widely used traditional herbal
medicines and its fruits have been used to treat a variety of
diseases in China, Vietnam, and Japan. 350 compounds have been
isolated and identified from C. monnieri, including the main active
constituent, coumarins. In vitro and in vivo studies suggest that
osthole and other coumarin compounds possess wide range of
pharmacological properties for the treatment of female genitals,
male impotence, frigidity, skin-related diseases, and exhibit
strong antipruritic, anti-allergic, antidermatophytic,
antibacterial, antifungal, anti-osteoporotic effects.
1.Osthole is widely used in fields of heath products. Osthole can
be used as the tonic product on
the male impotence, active ingredients of medicines for
2.Osthole is widely used in fields of medicine products. Osthole
also is used as the tonic product
on the acute exudative skin disease.
1.With the tonic effect on the male impotence, there is great
effect for treating impotence,it can increase sperm secretion,
stimulate sexual desire and has aphrodisiac action.
2.It can warm the kidney and relieve asthma.
3.With the role of anti-trichomonas, there is great effect for
common gynecological diseases of women.
4.It can dry dampness and kills worms as well as expel cold and the
5.With the good effect for treating acute exudative skin diseases.
Cnidium Monnieri Extract
Loss on Drying
Total Heavy Metals
Total Plate Count
Total Yeast & Mold
Osthole benefit for fatty liver:
Osthole improves fat milk-induced fatty liver in rats: modulation
of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
Planta Med. 2007.
The objectives of this study were to determine the therapeutic
effect of osthole, an active constituent isolated from Cnidium
monnieri, in hyperlipidemic fatty liver rats and investigate the
possible mechanism of the osthole treatment. Osthole exerts
therapeutic effects on fat milk-induced fatty liver in rats, by
regulating mRNA expression of the target genes of CYP7A, DGAT,
L-FABP and FATP4 via increasing the PPARalpha/gamma mRNA
Chemical aspects of coumarin compounds for the prevention of
Curr Med Chem Anti-Cancer Agents. 2005.
The normalization of plasma alanine aminotransferase (ALT) has been
proved to be a strategy for preventing the development of
hepatocellular carcinoma in hepatitis C virus (HCV)-infection.
Glycyrrhizin, a plant medicine, normalizes plasma ALT and prevents
HCC. However, glycyrrhizin is administered intravenously and
thereby chemical which is effective on oral administration is
required. Coumarin compounds are active components of herbs used
for the treatment of various diseases. The ability of coumarin
compounds to lower plasma ALT were examined using mice concanavalin
A-induced hepatitis and mice anti-Fas antibody-induced hepatitis.
We conclude that osthole will become a leading chemical for
synthesizing a compound which prevents liver cancer on oral